7K12
ACMSD in complex with diflunisal
Summary for 7K12
Entry DOI | 10.2210/pdb7k12/pdb |
Descriptor | 2-amino-3-carboxymuconate 6-semialdehyde decarboxylase, ZINC ION, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, ... (5 entities in total) |
Functional Keywords | fda-approved drugs, nad+, neuropsychiatric disorders, decarboxylase, lyase |
Biological source | Pseudomonas fluorescens |
Total number of polymer chains | 2 |
Total formula weight | 80134.52 |
Authors | |
Primary citation | Yang, Y.,Borel, T.,de Azambuja, F.,Johnson, D.,Sorrentino, J.P.,Udokwu, C.,Davis, I.,Liu, A.,Altman, R.A. Diflunisal Derivatives as Modulators of ACMS Decarboxylase Targeting the Tryptophan-Kynurenine Pathway. J.Med.Chem., 64:797-811, 2021 Cited by PubMed: 33369426DOI: 10.1021/acs.jmedchem.0c01762 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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