7K0U

Crystal structure of the second bromodomain (BD2) of human TAF1 bound to PLK1 kinase inhibitor BI2536

7K0U の概要

• エントリーDOI: 10.2210/pdb7k0u/pdb
• 分子名称: Transcription initiation factor TFIID subunit 1, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide (3 entities in total)
• 機能のキーワード: taf1, non-bet, bet, kinase inhibitor, plk1, dual brd-kinase, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33852.24

構造登録者

Karim, M.R.,Schonbrunn, E. (登録日: 2020-09-06, 公開日: 2021-09-22, 最終更新日: 2023-10-18)

• 主引用文献: Karim, R.M.,Yang, L.,Chen, L.,Bikowitz, M.J.,Lu, J.,Grassie, D.,Shultz, Z.P.,Lopchuk, J.M.,Chen, J.,Schonbrunn, E.; Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.; J.Med.Chem., 65:4182-4200, 2022; PubMed: 35191694; DOI: 10.1021/acs.jmedchem.1c01999

実験手法

X-RAY DIFFRACTION (2.52 Å)