7JYT

hALK in complex with 3-(3-methyl-1H-pyrazol-5-yl)pyridine

Summary for 7JYT

Entry DOI	10.2210/pdb7jyt/pdb
Related	7JY4 7JYR 7JYS
Descriptor	ALK tyrosine kinase receptor, GLYCEROL, 3-(3-methyl-1H-pyrazol-5-yl)pyridine, ... (4 entities in total)
Functional Keywords	alk tyrosine kinase receptor, inhibitor, complex, kinase, sbdd, transferase-inhibitor complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36296.65
Authors	McGrath, A.P.,Zou, H.,Lane, W.,Saikatendu, K. (deposition date: 2020-08-31, release date: 2021-01-20, Last modification date: 2023-10-18)
Primary citation	Fujimori, I.,Wakabayashi, T.,Murakami, M.,Okabe, A.,Ishii, T.,McGrath, A.,Zou, H.,Saikatendu, K.S.,Imoto, H. Discovery of Novel and Highly Selective Cyclopropane ALK Inhibitors through a Fragment-Assisted, Structure-Based Drug Design. Acs Omega, 5:31984-32001, 2020 Cited by PubMed: 33344853 DOI: 10.1021/acsomega.0c04900 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation