7JWZ
IPI-549 bound to the PI3Kg catalytic subunit p110 gamma
Summary for 7JWZ
Entry DOI | 10.2210/pdb7jwz/pdb |
Related | 7JWE |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (2 entities in total) |
Functional Keywords | pi3k, inhibitor, phosphoinositides, p110, pik3cg, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 111255.67 |
Authors | Burke, J.E.,Rathinaswamy, M.K.,Harris, N.J. (deposition date: 2020-08-26, release date: 2021-03-17, Last modification date: 2023-10-18) |
Primary citation | Rathinaswamy, M.K.,Gaieb, Z.,Fleming, K.D.,Borsari, C.,Harris, N.J.,Moeller, B.J.,Wymann, M.P.,Amaro, R.E.,Burke, J.E. Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. Elife, 10:-, 2021 Cited by PubMed: 33661099DOI: 10.7554/eLife.64691 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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