7JWZ

IPI-549 bound to the PI3Kg catalytic subunit p110 gamma

7JWZ の概要

• エントリーDOI: 10.2210/pdb7jwz/pdb
• 関連するPDBエントリー: 7JWE
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-N-[(1S)-1-{8-[(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl}ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide (2 entities in total)
• 機能のキーワード: pi3k, inhibitor, phosphoinositides, p110, pik3cg, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111255.67

構造登録者

Burke, J.E.,Rathinaswamy, M.K.,Harris, N.J. (登録日: 2020-08-26, 公開日: 2021-03-17, 最終更新日: 2023-10-18)

• 主引用文献: Rathinaswamy, M.K.,Gaieb, Z.,Fleming, K.D.,Borsari, C.,Harris, N.J.,Moeller, B.J.,Wymann, M.P.,Amaro, R.E.,Burke, J.E.; Disease related mutations in PI3K gamma disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors.; Elife, 10:-, 2021; PubMed: 33661099; DOI: 10.7554/eLife.64691

実験手法

X-RAY DIFFRACTION (2.65 Å)