7JW7

Structure of monobody 27 human MLKL pseudokinase domain complex

7JW7 の概要

• エントリーDOI: 10.2210/pdb7jw7/pdb
• 分子名称: Mixed lineage kinase domain-like protein, Monobody 27 (3 entities in total)
• 機能のキーワード: pseudokinase, monobody, complex, necroptosis, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43403.42

構造登録者

Meng, Y.,Garnish, S.E.,Koide, A.,Koide, S.,Czabotar, P.E.,Murphy, J.M. (登録日: 2020-08-25, 公開日: 2021-03-10, 最終更新日: 2023-10-18)

• 主引用文献: Garnish, S.E.,Meng, Y.,Koide, A.,Sandow, J.J.,Denbaum, E.,Jacobsen, A.V.,Yeung, W.,Samson, A.L.,Horne, C.R.,Fitzgibbon, C.,Young, S.N.,Smith, P.P.C.,Webb, A.I.,Petrie, E.J.,Hildebrand, J.M.,Kannan, N.,Czabotar, P.E.,Koide, S.,Murphy, J.M.; Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.; Nat Commun, 12:2211-2211, 2021; PubMed: 33850121; DOI: 10.1038/s41467-021-22400-z

実験手法

X-RAY DIFFRACTION (2.63 Å)