7JVX

Crystal structure of PTEN (aa 7-353 followed by spacer TGGGSGGTGGGSGGTGGGCY ligated to peptide pSDpTpTDpSDPENEPFDED)

7JVX の概要

• エントリーDOI: 10.2210/pdb7jvx/pdb
• 分子名称: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, PHOSPHATE ION (2 entities in total)
• 機能のキーワード: phosphatase, phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten, signaling protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48745.43

構造登録者

Dempsey, D.,Phan, K.,Cole, P.,Gabelli, S.B. (登録日: 2020-08-24, 公開日: 2021-08-04, 最終更新日: 2023-10-18)

• 主引用文献: Dempsey, D.R.,Viennet, T.,Iwase, R.,Park, E.,Henriquez, S.,Chen, Z.,Jeliazkov, J.R.,Palanski, B.A.,Phan, K.L.,Coote, P.,Gray, J.J.,Eck, M.J.,Gabelli, S.B.,Arthanari, H.,Cole, P.A.; The structural basis of PTEN regulation by multi-site phosphorylation.; Nat.Struct.Mol.Biol., 28:858-868, 2021; PubMed: 34625746; DOI: 10.1038/s41594-021-00668-5

実験手法

X-RAY DIFFRACTION (3.2 Å)