7JVW
Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344
Summary for 7JVW
Entry DOI | 10.2210/pdb7jvw/pdb |
Descriptor | Histone deacetylase 8, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | histone deacetylase, hydrolase, cornelia de lange syndrome (cdls) |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 87566.26 |
Authors | Osko, J.D.,Christianson, D.W.,Decroos, C.,Porter, N.J.,Lee, M. (deposition date: 2020-08-24, release date: 2020-12-16, Last modification date: 2023-10-18) |
Primary citation | Osko, J.D.,Porter, N.J.,Decroos, C.,Lee, M.S.,Watson, P.R.,Raible, S.E.,Krantz, I.D.,Deardorff, M.A.,Christianson, D.W. Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213:107681-107681, 2020 Cited by PubMed: 33316326DOI: 10.1016/j.jsb.2020.107681 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.40301779656 Å) |
Structure validation
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