7JVW

Crystal structure of human histone deacetylase 8 (HDAC8) G320R mutation complexed with M344

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone deacetylase 8	polymer	389	43332.1	2	UniProt (Q9BY41) Pfam (PF00850)	Homo sapiens (Human)	HD8
2	C, G (A, B)	4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide	non-polymer		307.4	2	Chemie (B3N)
3	D, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, F, I, J (A, B)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
5	K, L (A, B)	water	water		18.0	143	Chemie (HOH)

Sequence modifications

A, B: 1 - 377 (UniProt: Q9BY41)

PDB	External Database	Details
Arg 320	Gly 320	engineered mutation
Ile 378	-	expression tag
Glu 379	-	expression tag
Gly 380	-	expression tag
Arg 381	-	expression tag
Gly 382	-	expression tag
Ser 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86664.3
Non-Polymers*	Number of molecules	8
	Total formula weight	902.0
All*	Total formula weight	87566.3

*Water molecules are not included.