7JVU

Crystal structure of human histone deacetylase 8 (HDAC8) I45T mutation complexed with SAHA

Summary for 7JVU

Entry DOI	10.2210/pdb7jvu/pdb
Descriptor	Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	histone deacetylase, hydrolase, cornelia de lange syndrome (cdls)
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	87690.20
Authors	Osko, J.D.,Christianson, D.W.,Decroos, C.,Porter, N.J.,Lee, M. (deposition date: 2020-08-24, release date: 2020-12-16, Last modification date: 2023-10-18)
Primary citation	Osko, J.D.,Porter, N.J.,Decroos, C.,Lee, M.S.,Watson, P.R.,Raible, S.E.,Krantz, I.D.,Deardorff, M.A.,Christianson, D.W. Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J.Struct.Biol., 213:107681-107681, 2020 Cited by PubMed: 33316326 DOI: 10.1016/j.jsb.2020.107681 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5004765401 Å)

Structure validation