7JVU

Crystal structure of human histone deacetylase 8 (HDAC8) I45T mutation complexed with SAHA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histone deacetylase 8	polymer	389	43219.9	2	UniProt (Q9BY41) Pfam (PF00850)	Homo sapiens (Human)	HD8
2	C, K (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, E, L, M (A, B)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
4	F, N (A, B)	OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE	non-polymer		264.3	2	Chemie (SHH)
5	G, H, I, J, O... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
6	R, S (A, B)	water	water		18.0	635	Chemie (HOH)

Sequence modifications

A, B: 1 - 377 (UniProt: Q9BY41)

PDB	External Database	Details
Thr 45	Ile 45	engineered mutation
Ile 378	-	expression tag
Glu 379	-	expression tag
Gly 380	-	expression tag
Arg 381	-	expression tag
Gly 382	-	expression tag
Ser 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	86439.9
Non-Polymers*	Number of molecules	15
	Total formula weight	1250.3
All*	Total formula weight	87690.2

*Water molecules are not included.