7JVN

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24

7JVN の概要

• エントリーDOI: 10.2210/pdb7jvn/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: phosphatase ptp, inhibitor, ptpn11, allosteric, shp2, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121929.37

構造登録者

Fodor, M.,Stams, T. (登録日: 2020-08-21, 公開日: 2020-09-23, 最終更新日: 2023-10-18)

• 主引用文献: LaMarche, M.J.,Acker, M.,Argintaru, A.,Bauer, D.,Boisclair, J.,Chan, H.,Chen, C.H.,Chen, Y.N.,Chen, Z.,Deng, Z.,Dore, M.,Dunstan, D.,Fan, J.,Fekkes, P.,Firestone, B.,Fodor, M.,Garcia-Fortanet, J.,Fortin, P.D.,Fridrich, C.,Giraldes, J.,Glick, M.,Grunenfelder, D.,Hao, H.X.,Hentemann, M.,Ho, S.,Jouk, A.,Kang, Z.B.,Karki, R.,Kato, M.,Keen, N.,Koenig, R.,LaBonte, L.R.,Larrow, J.,Liu, G.,Liu, S.,Majumdar, D.,Mathieu, S.,Meyer, M.J.,Mohseni, M.,Ntaganda, R.,Palermo, M.,Perez, L.,Pu, M.,Ramsey, T.,Reilly, J.,Sarver, P.,Sellers, W.R.,Sendzik, M.,Shultz, M.D.,Slisz, J.,Slocum, K.,Smith, T.,Spence, S.,Stams, T.,Straub, C.,Tamez Jr., V.,Toure, B.B.,Towler, C.,Wang, P.,Wang, H.,Williams, S.L.,Yang, F.,Yu, B.,Zhang, J.H.,Zhu, S.; Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.; J.Med.Chem., 63:13578-13594, 2020; PubMed: 32910655; DOI: 10.1021/acs.jmedchem.0c01170

実験手法

X-RAY DIFFRACTION (1.917 Å)