7JU8

X-ray structure of MMP-13 in Complex with 4-(1,2,3-thiadiazol-4-yl)pyridine

Summary for 7JU8

• Entry DOI: 10.2210/pdb7ju8/pdb
• Descriptor: Collagenase 3, ZINC ION, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 40069.79

Authors

Farrow, N.A. (deposition date: 2020-08-19, release date: 2021-08-04, Last modification date: 2023-10-18)

• Primary citation: Taylor, S.J.,Abeywardane, A.,Liang, S.,Xiong, Z.,Proudfoot, J.R.,Farmer, B.S.,Gao, D.A.,Heim-Riether, A.,Smith-Keenan, L.L.,Muegge, I.,Yu, Y.,Zhang, Q.,Souza, D.,Panzenbeck, M.,Goldberg, D.,Hill-Drzewi, M.,Margarit, M.,Collins, B.,Li, J.X.,Zuvela-Jelaska, L.,Li, J.,Farrow, N.A.; Indole Inhibitors of MMP-13 for Arthritic Disorders; Acs Omega, 6:18635-18650, 2021; DOI: 10.1021/acsomega.1c01320

Experimental method

X-RAY DIFFRACTION (2 Å)