7JTO
Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Summary for 7JTO
Entry DOI | 10.2210/pdb7jto/pdb |
Descriptor | WD repeat-containing protein 5, Elongin-B, Elongin-C, ... (10 entities in total) |
Functional Keywords | protac, protein degradation, ubiquitination, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 77329.19 |
Authors | Kottur, J.,Jain, R.,Aggarwal, A.K. (deposition date: 2020-08-18, release date: 2021-10-06, Last modification date: 2023-10-18) |
Primary citation | Yu, X.,Li, D.,Kottur, J.,Shen, Y.,Kim, H.S.,Park, K.S.,Tsai, Y.H.,Gong, W.,Wang, J.,Suzuki, K.,Parker, J.,Herring, L.,Kaniskan, H.U.,Cai, L.,Jain, R.,Liu, J.,Aggarwal, A.K.,Wang, G.G.,Jin, J. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13:eabj1578-eabj1578, 2021 Cited by PubMed: 34586829DOI: 10.1126/scitranslmed.abj1578 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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