7JOV

CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A PHENYLPYRAZOLE AMIDE INHIBITOR

7JOV の概要

• エントリーDOI: 10.2210/pdb7jov/pdb
• 分子名称: Rho-associated protein kinase 2, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide, ... (5 entities in total)
• 機能のキーワード: rock1, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 366400.97

構造登録者

Muckelbauer, J.K. (登録日: 2020-08-07, 公開日: 2020-09-02, 最終更新日: 2024-03-06)

• 主引用文献: Hu, Z.,Wang, C.,Glunz, P.W.,Li, J.,Cheadle, N.L.,Chen, A.Y.,Chen, X.Q.,Myers, J.E.,Guarino, V.R.,Rose, A.,Sack, J.S.,Sitkoff, D.,Taylor, D.S.,Xu, S.,Yan, C.,Zhang, H.,Zhang, L.,Hennan, J.,Adam, L.P.,Wexler, R.R.,Quan, M.L.; Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.; Bioorg.Med.Chem.Lett., 30:127495-127495, 2020; PubMed: 32798651; DOI: 10.1016/j.bmcl.2020.127495

実験手法

X-RAY DIFFRACTION (2.586 Å)