7JNX

Carbonic Anhydrase II Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide

Summary for 7JNX

Entry DOI	10.2210/pdb7jnx/pdb
Descriptor	Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... (6 entities in total)
Functional Keywords	carbonic anhydrase, ca inhibitor, structure guided drug design, carbonic anhydrase ii, carbonic anhydrase ix, caii, caix, sulfonamide, lyase, lyase-inhibitor complex, lyase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29789.02
Authors	Andring, J.T.,McKenna, R. (deposition date: 2020-08-05, release date: 2020-11-04, Last modification date: 2023-10-18)
Primary citation	Andring, J.T.,Fouch, M.,Akocak, S.,Angeli, A.,Supuran, C.T.,Ilies, M.A.,McKenna, R. Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone. J.Med.Chem., 63:13064-13075, 2020 Cited by PubMed: 33085484 DOI: 10.1021/acs.jmedchem.0c01390 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.286 Å)

Structure validation