7JMT

Crystal structure of schistosome BCL-2 bound to ABT-737

7JMT の概要

• エントリーDOI: 10.2210/pdb7jmt/pdb
• 分子名称: BCL-2 protein, 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE (3 entities in total)
• 機能のキーワード: apoptosis
• 由来する生物種: Schistosoma japonicum (Blood fluke)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 145380.47

構造登録者

Smith, N.A.,Smith, B.J.,Lee, E.F.,Colman, P.M.,Fairlie, W.D. (登録日: 2020-08-02, 公開日: 2021-02-17, 最終更新日: 2023-10-18)

• 主引用文献: Nguyen, W.,Lee, E.F.,Evangelista, M.,Lee, M.,Harris, T.J.,Colman, P.M.,Smith, N.A.,Williams, L.B.,Jarman, K.E.,Lowes, K.N.,Haeberli, C.,Keiser, J.,Smith, B.J.,Fairlie, W.D.,Sleebs, B.E.; Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.; Acs Infect Dis., 7:1143-1163, 2021; PubMed: 33523649; DOI: 10.1021/acsinfecdis.0c00700

実験手法

X-RAY DIFFRACTION (2.75 Å)