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7JKZ

Bromodomain-containing protein 4 (BRD4) bromodomain 2 (BD2) complexed with YF3-126

7JKZ の概要
エントリーDOI10.2210/pdb7jkz/pdb
分子名称Bromodomain-containing protein 4, N-(1-[1,1-di(pyridin-2-yl)ethyl]-6-{1-methyl-6-oxo-5-[(piperidin-4-yl)amino]-1,6-dihydropyridin-3-yl}-1H-indol-4-yl)ethanesulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
機能のキーワードselective brd4-bd1 inhibitor, transcription
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数1
化学式量合計15826.25
構造登録者
Ratia, K.M.,Xiong, R.,Li, Y.,Shen, Z.,Zhao, J.,Huang, F.,Dubrovyskyii, O.,Thatcher, G.R. (登録日: 2020-07-29, 公開日: 2021-08-25, 最終更新日: 2023-10-18)
主引用文献Li, Y.,Zhao, J.,Gutgesell, L.M.,Shen, Z.,Ratia, K.,Dye, K.,Dubrovskyi, O.,Zhao, H.,Huang, F.,Tonetti, D.A.,Thatcher, G.R.J.,Xiong, R.
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
J.Med.Chem., 63:7186-7210, 2020
Cited by
PubMed: 32453591
DOI: 10.1021/acs.jmedchem.0c00456
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.49 Å)
構造検証レポート
Validation report summary of 7jkz
検証レポート(詳細版)ダウンロードをダウンロード

221051

件を2024-06-12に公開中

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