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7JK7

Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant

Summary for 7JK7
Entry DOI10.2210/pdb7jk7/pdb
DescriptorLysine-specific histone demethylase 1A, Importin subunit alpha-1, GLYCEROL, ... (4 entities in total)
Functional Keywordsimportin alpha demethylase nuclear localisation, protein transport
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight54525.69
Authors
Primary citationTu, W.J.,McCuaig, R.D.,Tan, A.H.Y.,Hardy, K.,Seddiki, N.,Ali, S.,Dahlstrom, J.E.,Bean, E.G.,Dunn, J.,Forwood, J.,Tsimbalyuk, S.,Smith, K.,Yip, D.,Malik, L.,Prasanna, T.,Milburn, P.,Rao, S.
Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11:1228-, 2020
Cited by
DOI: 10.3389/fimmu.2020.01228
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.96 Å)
Structure validation

217705

数据于2024-03-27公开中

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