7JK7

Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant

7JK7 の概要

• エントリーDOI: 10.2210/pdb7jk7/pdb
• 分子名称: Lysine-specific histone demethylase 1A, Importin subunit alpha-1, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: importin alpha demethylase nuclear localisation, protein transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54525.69

構造登録者

Tu, W.J.,McCuaig, R.,Tan, A.H.Y.,Hardy, K.,Seddiki, N.,Ali, S.,Dahlstron, J.E.,Bean, E.G.,Dunn, J.,Forwood, J.K.,Tsimbalyuk, S.,Smith, K.M.,Yip, D.,Malik, L.,Prasana, T.,Milburn, P.,Rao, S. (登録日: 2020-07-27, 公開日: 2020-08-05, 最終更新日: 2023-10-18)

• 主引用文献: Tu, W.J.,McCuaig, R.D.,Tan, A.H.Y.,Hardy, K.,Seddiki, N.,Ali, S.,Dahlstrom, J.E.,Bean, E.G.,Dunn, J.,Forwood, J.,Tsimbalyuk, S.,Smith, K.,Yip, D.,Malik, L.,Prasanna, T.,Milburn, P.,Rao, S.; Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.; Front Immunol, 11:1228-, 2020; DOI: 10.3389/fimmu.2020.01228

実験手法

X-RAY DIFFRACTION (1.96 Å)