7JGL

Crystal Structure of the Zn-bound Human Heavy-chain variant 122H-delta C-star with 2,5-furandihyrdoxamate collected at 100K

これはPDB形式変換不可エントリーです。

7JGL の概要

• エントリーDOI: 10.2210/pdb7jgl/pdb
• 関連するPDBエントリー: 5CMQ 5CMR 5UP8 5UP9
• 分子名称: Ferritin heavy chain, ZINC ION, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: protein-mof, ferritin-mof, self-assembly, ferritin, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 48
• 化学式量合計: 1023837.50

構造登録者

Bailey, J.B.,Tezcan, F.A. (登録日: 2020-07-19, 公開日: 2020-10-21, 最終更新日: 2023-10-18)

主引用文献

Bailey, J.B.,Tezcan, F.A.
Tunable and Cooperative Thermomechanical Properties of Protein-Metal-Organic Frameworks.
J.Am.Chem.Soc., 142:17265-17270, 2020

PubMed Abstract: We recently introduced protein-metal-organic frameworks (protein-MOFs) as chemically designed protein crystals, composed of ferritin nodes that predictably assemble into 3D lattices upon coordination of various metal ions and ditopic, hydroxamate-based linkers. Owing to their unique tripartite construction, protein-MOFs possess extremely sparse lattice connectivity, suggesting that they might display unusual thermomechanical properties. Leveraging the synthetic modularity of ferritin-MOFs, we investigated the temperature-dependent structural dynamics of six distinct frameworks. Our results show that the thermostabilities of ferritin-MOFs can be tuned through the metal component or the presence of crowding agents. Our studies also reveal a framework that undergoes a reversible and isotropic first-order phase transition near-room temperature, corresponding to a 4% volumetric change within 1 °C and a hysteresis window of ∼10 °C. This highly cooperative crystal-to-crystal transformation, which stems from the soft crystallinity of ferritin-MOFs, illustrates the advantage of modular construction strategies in discovering tunable-and unpredictable-material properties.

PubMed: 32972136
DOI: 10.1021/jacs.0c07835

実験手法

X-RAY DIFFRACTION (2.34 Å)