7JGL

Crystal Structure of the Zn-bound Human Heavy-chain variant 122H-delta C-star with 2,5-furandihyrdoxamate collected at 100K

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0004322	molecular_function	ferroxidase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005776	cellular_component	autophagosome
B	0005829	cellular_component	cytosol
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0008285	biological_process	negative regulation of cell population proliferation
B	0016491	molecular_function	oxidoreductase activity
B	0031410	cellular_component	cytoplasmic vesicle
B	0042802	molecular_function	identical protein binding
B	0044754	cellular_component	autolysosome
B	0046872	molecular_function	metal ion binding
B	0048147	biological_process	negative regulation of fibroblast proliferation
B	0070062	cellular_component	extracellular exosome
B	0070288	cellular_component	ferritin complex
B	0110076	biological_process	negative regulation of ferroptosis
B	0140315	molecular_function	iron ion sequestering activity
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004322	molecular_function	ferroxidase activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005829	cellular_component	cytosol
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006955	biological_process	immune response
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016491	molecular_function	oxidoreductase activity
C	0031410	cellular_component	cytoplasmic vesicle
C	0042802	molecular_function	identical protein binding
C	0044754	cellular_component	autolysosome
C	0046872	molecular_function	metal ion binding
C	0048147	biological_process	negative regulation of fibroblast proliferation
C	0070062	cellular_component	extracellular exosome
C	0070288	cellular_component	ferritin complex
C	0110076	biological_process	negative regulation of ferroptosis
C	0140315	molecular_function	iron ion sequestering activity
C	1904724	cellular_component	tertiary granule lumen
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0004322	molecular_function	ferroxidase activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0005829	cellular_component	cytosol
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0008285	biological_process	negative regulation of cell population proliferation
D	0016491	molecular_function	oxidoreductase activity
D	0031410	cellular_component	cytoplasmic vesicle
D	0042802	molecular_function	identical protein binding
D	0044754	cellular_component	autolysosome
D	0046872	molecular_function	metal ion binding
D	0048147	biological_process	negative regulation of fibroblast proliferation
D	0070062	cellular_component	extracellular exosome
D	0070288	cellular_component	ferritin complex
D	0110076	biological_process	negative regulation of ferroptosis
D	0140315	molecular_function	iron ion sequestering activity
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0004322	molecular_function	ferroxidase activity
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005776	cellular_component	autophagosome
E	0005829	cellular_component	cytosol
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016491	molecular_function	oxidoreductase activity
E	0031410	cellular_component	cytoplasmic vesicle
E	0042802	molecular_function	identical protein binding
E	0044754	cellular_component	autolysosome
E	0046872	molecular_function	metal ion binding
E	0048147	biological_process	negative regulation of fibroblast proliferation
E	0070062	cellular_component	extracellular exosome
E	0070288	cellular_component	ferritin complex
E	0110076	biological_process	negative regulation of ferroptosis
E	0140315	molecular_function	iron ion sequestering activity
E	1904724	cellular_component	tertiary granule lumen
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0004322	molecular_function	ferroxidase activity
F	0005506	molecular_function	iron ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005776	cellular_component	autophagosome
F	0005829	cellular_component	cytosol
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0008285	biological_process	negative regulation of cell population proliferation
F	0016491	molecular_function	oxidoreductase activity
F	0031410	cellular_component	cytoplasmic vesicle
F	0042802	molecular_function	identical protein binding
F	0044754	cellular_component	autolysosome
F	0046872	molecular_function	metal ion binding
F	0048147	biological_process	negative regulation of fibroblast proliferation
F	0070062	cellular_component	extracellular exosome
F	0070288	cellular_component	ferritin complex
F	0110076	biological_process	negative regulation of ferroptosis
F	0140315	molecular_function	iron ion sequestering activity
F	1904724	cellular_component	tertiary granule lumen
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0004322	molecular_function	ferroxidase activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0005776	cellular_component	autophagosome
G	0005829	cellular_component	cytosol
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016491	molecular_function	oxidoreductase activity
G	0031410	cellular_component	cytoplasmic vesicle
G	0042802	molecular_function	identical protein binding
G	0044754	cellular_component	autolysosome
G	0046872	molecular_function	metal ion binding
G	0048147	biological_process	negative regulation of fibroblast proliferation
G	0070062	cellular_component	extracellular exosome
G	0070288	cellular_component	ferritin complex
G	0110076	biological_process	negative regulation of ferroptosis
G	0140315	molecular_function	iron ion sequestering activity
G	1904724	cellular_component	tertiary granule lumen
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0004322	molecular_function	ferroxidase activity
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0005776	cellular_component	autophagosome
H	0005829	cellular_component	cytosol
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0008285	biological_process	negative regulation of cell population proliferation
H	0016491	molecular_function	oxidoreductase activity
H	0031410	cellular_component	cytoplasmic vesicle
H	0042802	molecular_function	identical protein binding
H	0044754	cellular_component	autolysosome
H	0046872	molecular_function	metal ion binding
H	0048147	biological_process	negative regulation of fibroblast proliferation
H	0070062	cellular_component	extracellular exosome
H	0070288	cellular_component	ferritin complex
H	0110076	biological_process	negative regulation of ferroptosis
H	0140315	molecular_function	iron ion sequestering activity
H	1904724	cellular_component	tertiary granule lumen
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0004322	molecular_function	ferroxidase activity
I	0005506	molecular_function	iron ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0005776	cellular_component	autophagosome
I	0005829	cellular_component	cytosol
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006955	biological_process	immune response
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0008285	biological_process	negative regulation of cell population proliferation
I	0016491	molecular_function	oxidoreductase activity
I	0031410	cellular_component	cytoplasmic vesicle
I	0042802	molecular_function	identical protein binding
I	0044754	cellular_component	autolysosome
I	0046872	molecular_function	metal ion binding
I	0048147	biological_process	negative regulation of fibroblast proliferation
I	0070062	cellular_component	extracellular exosome
I	0070288	cellular_component	ferritin complex
I	0110076	biological_process	negative regulation of ferroptosis
I	0140315	molecular_function	iron ion sequestering activity
I	1904724	cellular_component	tertiary granule lumen
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0004322	molecular_function	ferroxidase activity
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0005776	cellular_component	autophagosome
J	0005829	cellular_component	cytosol
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006955	biological_process	immune response
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0008285	biological_process	negative regulation of cell population proliferation
J	0016491	molecular_function	oxidoreductase activity
J	0031410	cellular_component	cytoplasmic vesicle
J	0042802	molecular_function	identical protein binding
J	0044754	cellular_component	autolysosome
J	0046872	molecular_function	metal ion binding
J	0048147	biological_process	negative regulation of fibroblast proliferation
J	0070062	cellular_component	extracellular exosome
J	0070288	cellular_component	ferritin complex
J	0110076	biological_process	negative regulation of ferroptosis
J	0140315	molecular_function	iron ion sequestering activity
J	1904724	cellular_component	tertiary granule lumen
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0004322	molecular_function	ferroxidase activity
K	0005506	molecular_function	iron ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0005776	cellular_component	autophagosome
K	0005829	cellular_component	cytosol
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0008285	biological_process	negative regulation of cell population proliferation
K	0016491	molecular_function	oxidoreductase activity
K	0031410	cellular_component	cytoplasmic vesicle
K	0042802	molecular_function	identical protein binding
K	0044754	cellular_component	autolysosome
K	0046872	molecular_function	metal ion binding
K	0048147	biological_process	negative regulation of fibroblast proliferation
K	0070062	cellular_component	extracellular exosome
K	0070288	cellular_component	ferritin complex
K	0110076	biological_process	negative regulation of ferroptosis
K	0140315	molecular_function	iron ion sequestering activity
K	1904724	cellular_component	tertiary granule lumen
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0004322	molecular_function	ferroxidase activity
L	0005506	molecular_function	iron ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0005776	cellular_component	autophagosome
L	0005829	cellular_component	cytosol
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0008285	biological_process	negative regulation of cell population proliferation
L	0016491	molecular_function	oxidoreductase activity
L	0031410	cellular_component	cytoplasmic vesicle
L	0042802	molecular_function	identical protein binding
L	0044754	cellular_component	autolysosome
L	0046872	molecular_function	metal ion binding
L	0048147	biological_process	negative regulation of fibroblast proliferation
L	0070062	cellular_component	extracellular exosome
L	0070288	cellular_component	ferritin complex
L	0110076	biological_process	negative regulation of ferroptosis
L	0140315	molecular_function	iron ion sequestering activity
L	1904724	cellular_component	tertiary granule lumen
L	1904813	cellular_component	ficolin-1-rich granule lumen
M	0004322	molecular_function	ferroxidase activity
M	0005506	molecular_function	iron ion binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005764	cellular_component	lysosome
M	0005776	cellular_component	autophagosome
M	0005829	cellular_component	cytosol
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0006955	biological_process	immune response
M	0008198	molecular_function	ferrous iron binding
M	0008199	molecular_function	ferric iron binding
M	0008285	biological_process	negative regulation of cell population proliferation
M	0016491	molecular_function	oxidoreductase activity
M	0031410	cellular_component	cytoplasmic vesicle
M	0042802	molecular_function	identical protein binding
M	0044754	cellular_component	autolysosome
M	0046872	molecular_function	metal ion binding
M	0048147	biological_process	negative regulation of fibroblast proliferation
M	0070062	cellular_component	extracellular exosome
M	0070288	cellular_component	ferritin complex
M	0110076	biological_process	negative regulation of ferroptosis
M	0140315	molecular_function	iron ion sequestering activity
M	1904724	cellular_component	tertiary granule lumen
M	1904813	cellular_component	ficolin-1-rich granule lumen
N	0004322	molecular_function	ferroxidase activity
N	0005506	molecular_function	iron ion binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005764	cellular_component	lysosome
N	0005776	cellular_component	autophagosome
N	0005829	cellular_component	cytosol
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006955	biological_process	immune response
N	0008198	molecular_function	ferrous iron binding
N	0008199	molecular_function	ferric iron binding
N	0008285	biological_process	negative regulation of cell population proliferation
N	0016491	molecular_function	oxidoreductase activity
N	0031410	cellular_component	cytoplasmic vesicle
N	0042802	molecular_function	identical protein binding
N	0044754	cellular_component	autolysosome
N	0046872	molecular_function	metal ion binding
N	0048147	biological_process	negative regulation of fibroblast proliferation
N	0070062	cellular_component	extracellular exosome
N	0070288	cellular_component	ferritin complex
N	0110076	biological_process	negative regulation of ferroptosis
N	0140315	molecular_function	iron ion sequestering activity
N	1904724	cellular_component	tertiary granule lumen
N	1904813	cellular_component	ficolin-1-rich granule lumen
O	0004322	molecular_function	ferroxidase activity
O	0005506	molecular_function	iron ion binding
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005764	cellular_component	lysosome
O	0005776	cellular_component	autophagosome
O	0005829	cellular_component	cytosol
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0006955	biological_process	immune response
O	0008198	molecular_function	ferrous iron binding
O	0008199	molecular_function	ferric iron binding
O	0008285	biological_process	negative regulation of cell population proliferation
O	0016491	molecular_function	oxidoreductase activity
O	0031410	cellular_component	cytoplasmic vesicle
O	0042802	molecular_function	identical protein binding
O	0044754	cellular_component	autolysosome
O	0046872	molecular_function	metal ion binding
O	0048147	biological_process	negative regulation of fibroblast proliferation
O	0070062	cellular_component	extracellular exosome
O	0070288	cellular_component	ferritin complex
O	0110076	biological_process	negative regulation of ferroptosis
O	0140315	molecular_function	iron ion sequestering activity
O	1904724	cellular_component	tertiary granule lumen
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0004322	molecular_function	ferroxidase activity
P	0005506	molecular_function	iron ion binding
P	0005515	molecular_function	protein binding
P	0005576	cellular_component	extracellular region
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005764	cellular_component	lysosome
P	0005776	cellular_component	autophagosome
P	0005829	cellular_component	cytosol
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0006955	biological_process	immune response
P	0008198	molecular_function	ferrous iron binding
P	0008199	molecular_function	ferric iron binding
P	0008285	biological_process	negative regulation of cell population proliferation
P	0016491	molecular_function	oxidoreductase activity
P	0031410	cellular_component	cytoplasmic vesicle
P	0042802	molecular_function	identical protein binding
P	0044754	cellular_component	autolysosome
P	0046872	molecular_function	metal ion binding
P	0048147	biological_process	negative regulation of fibroblast proliferation
P	0070062	cellular_component	extracellular exosome
P	0070288	cellular_component	ferritin complex
P	0110076	biological_process	negative regulation of ferroptosis
P	0140315	molecular_function	iron ion sequestering activity
P	1904724	cellular_component	tertiary granule lumen
P	1904813	cellular_component	ficolin-1-rich granule lumen
Q	0004322	molecular_function	ferroxidase activity
Q	0005506	molecular_function	iron ion binding
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005764	cellular_component	lysosome
Q	0005776	cellular_component	autophagosome
Q	0005829	cellular_component	cytosol
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006955	biological_process	immune response
Q	0008198	molecular_function	ferrous iron binding
Q	0008199	molecular_function	ferric iron binding
Q	0008285	biological_process	negative regulation of cell population proliferation
Q	0016491	molecular_function	oxidoreductase activity
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0042802	molecular_function	identical protein binding
Q	0044754	cellular_component	autolysosome
Q	0046872	molecular_function	metal ion binding
Q	0048147	biological_process	negative regulation of fibroblast proliferation
Q	0070062	cellular_component	extracellular exosome
Q	0070288	cellular_component	ferritin complex
Q	0110076	biological_process	negative regulation of ferroptosis
Q	0140315	molecular_function	iron ion sequestering activity
Q	1904724	cellular_component	tertiary granule lumen
Q	1904813	cellular_component	ficolin-1-rich granule lumen
R	0004322	molecular_function	ferroxidase activity
R	0005506	molecular_function	iron ion binding
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005764	cellular_component	lysosome
R	0005776	cellular_component	autophagosome
R	0005829	cellular_component	cytosol
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0006955	biological_process	immune response
R	0008198	molecular_function	ferrous iron binding
R	0008199	molecular_function	ferric iron binding
R	0008285	biological_process	negative regulation of cell population proliferation
R	0016491	molecular_function	oxidoreductase activity
R	0031410	cellular_component	cytoplasmic vesicle
R	0042802	molecular_function	identical protein binding
R	0044754	cellular_component	autolysosome
R	0046872	molecular_function	metal ion binding
R	0048147	biological_process	negative regulation of fibroblast proliferation
R	0070062	cellular_component	extracellular exosome
R	0070288	cellular_component	ferritin complex
R	0110076	biological_process	negative regulation of ferroptosis
R	0140315	molecular_function	iron ion sequestering activity
R	1904724	cellular_component	tertiary granule lumen
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0004322	molecular_function	ferroxidase activity
S	0005506	molecular_function	iron ion binding
S	0005515	molecular_function	protein binding
S	0005576	cellular_component	extracellular region
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005764	cellular_component	lysosome
S	0005776	cellular_component	autophagosome
S	0005829	cellular_component	cytosol
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0006955	biological_process	immune response
S	0008198	molecular_function	ferrous iron binding
S	0008199	molecular_function	ferric iron binding
S	0008285	biological_process	negative regulation of cell population proliferation
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S	1904724	cellular_component	tertiary granule lumen
S	1904813	cellular_component	ficolin-1-rich granule lumen
T	0004322	molecular_function	ferroxidase activity
T	0005506	molecular_function	iron ion binding
T	0005515	molecular_function	protein binding
T	0005576	cellular_component	extracellular region
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005764	cellular_component	lysosome
T	0005776	cellular_component	autophagosome
T	0005829	cellular_component	cytosol
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T	0006879	biological_process	intracellular iron ion homeostasis
T	0006955	biological_process	immune response
T	0008198	molecular_function	ferrous iron binding
T	0008199	molecular_function	ferric iron binding
T	0008285	biological_process	negative regulation of cell population proliferation
T	0016491	molecular_function	oxidoreductase activity
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T	0044754	cellular_component	autolysosome
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n	0005515	molecular_function	protein binding
n	0005576	cellular_component	extracellular region
n	0005634	cellular_component	nucleus
n	0005737	cellular_component	cytoplasm
n	0005764	cellular_component	lysosome
n	0005776	cellular_component	autophagosome
n	0005829	cellular_component	cytosol
n	0006826	biological_process	iron ion transport
n	0006879	biological_process	intracellular iron ion homeostasis
n	0006955	biological_process	immune response
n	0008198	molecular_function	ferrous iron binding
n	0008199	molecular_function	ferric iron binding
n	0008285	biological_process	negative regulation of cell population proliferation
n	0016491	molecular_function	oxidoreductase activity
n	0031410	cellular_component	cytoplasmic vesicle
n	0042802	molecular_function	identical protein binding
n	0044754	cellular_component	autolysosome
n	0046872	molecular_function	metal ion binding
n	0048147	biological_process	negative regulation of fibroblast proliferation
n	0070062	cellular_component	extracellular exosome
n	0070288	cellular_component	ferritin complex
n	0110076	biological_process	negative regulation of ferroptosis
n	0140315	molecular_function	iron ion sequestering activity
n	1904724	cellular_component	tertiary granule lumen
n	1904813	cellular_component	ficolin-1-rich granule lumen
o	0004322	molecular_function	ferroxidase activity
o	0005506	molecular_function	iron ion binding
o	0005515	molecular_function	protein binding
o	0005576	cellular_component	extracellular region
o	0005634	cellular_component	nucleus
o	0005737	cellular_component	cytoplasm
o	0005764	cellular_component	lysosome
o	0005776	cellular_component	autophagosome
o	0005829	cellular_component	cytosol
o	0006826	biological_process	iron ion transport
o	0006879	biological_process	intracellular iron ion homeostasis
o	0006955	biological_process	immune response
o	0008198	molecular_function	ferrous iron binding
o	0008199	molecular_function	ferric iron binding
o	0008285	biological_process	negative regulation of cell population proliferation
o	0016491	molecular_function	oxidoreductase activity
o	0031410	cellular_component	cytoplasmic vesicle
o	0042802	molecular_function	identical protein binding
o	0044754	cellular_component	autolysosome
o	0046872	molecular_function	metal ion binding
o	0048147	biological_process	negative regulation of fibroblast proliferation
o	0070062	cellular_component	extracellular exosome
o	0070288	cellular_component	ferritin complex
o	0110076	biological_process	negative regulation of ferroptosis
o	0140315	molecular_function	iron ion sequestering activity
o	1904724	cellular_component	tertiary granule lumen
o	1904813	cellular_component	ficolin-1-rich granule lumen
p	0004322	molecular_function	ferroxidase activity
p	0005506	molecular_function	iron ion binding
p	0005515	molecular_function	protein binding
p	0005576	cellular_component	extracellular region
p	0005634	cellular_component	nucleus
p	0005737	cellular_component	cytoplasm
p	0005764	cellular_component	lysosome
p	0005776	cellular_component	autophagosome
p	0005829	cellular_component	cytosol
p	0006826	biological_process	iron ion transport
p	0006879	biological_process	intracellular iron ion homeostasis
p	0006955	biological_process	immune response
p	0008198	molecular_function	ferrous iron binding
p	0008199	molecular_function	ferric iron binding
p	0008285	biological_process	negative regulation of cell population proliferation
p	0016491	molecular_function	oxidoreductase activity
p	0031410	cellular_component	cytoplasmic vesicle
p	0042802	molecular_function	identical protein binding
p	0044754	cellular_component	autolysosome
p	0046872	molecular_function	metal ion binding
p	0048147	biological_process	negative regulation of fibroblast proliferation
p	0070062	cellular_component	extracellular exosome
p	0070288	cellular_component	ferritin complex
p	0110076	biological_process	negative regulation of ferroptosis
p	0140315	molecular_function	iron ion sequestering activity
p	1904724	cellular_component	tertiary granule lumen
p	1904813	cellular_component	ficolin-1-rich granule lumen
q	0004322	molecular_function	ferroxidase activity
q	0005506	molecular_function	iron ion binding
q	0005515	molecular_function	protein binding
q	0005576	cellular_component	extracellular region
q	0005634	cellular_component	nucleus
q	0005737	cellular_component	cytoplasm
q	0005764	cellular_component	lysosome
q	0005776	cellular_component	autophagosome
q	0005829	cellular_component	cytosol
q	0006826	biological_process	iron ion transport
q	0006879	biological_process	intracellular iron ion homeostasis
q	0006955	biological_process	immune response
q	0008198	molecular_function	ferrous iron binding
q	0008199	molecular_function	ferric iron binding
q	0008285	biological_process	negative regulation of cell population proliferation
q	0016491	molecular_function	oxidoreductase activity
q	0031410	cellular_component	cytoplasmic vesicle
q	0042802	molecular_function	identical protein binding
q	0044754	cellular_component	autolysosome
q	0046872	molecular_function	metal ion binding
q	0048147	biological_process	negative regulation of fibroblast proliferation
q	0070062	cellular_component	extracellular exosome
q	0070288	cellular_component	ferritin complex
q	0110076	biological_process	negative regulation of ferroptosis
q	0140315	molecular_function	iron ion sequestering activity
q	1904724	cellular_component	tertiary granule lumen
q	1904813	cellular_component	ficolin-1-rich granule lumen
r	0004322	molecular_function	ferroxidase activity
r	0005506	molecular_function	iron ion binding
r	0005515	molecular_function	protein binding
r	0005576	cellular_component	extracellular region
r	0005634	cellular_component	nucleus
r	0005737	cellular_component	cytoplasm
r	0005764	cellular_component	lysosome
r	0005776	cellular_component	autophagosome
r	0005829	cellular_component	cytosol
r	0006826	biological_process	iron ion transport
r	0006879	biological_process	intracellular iron ion homeostasis
r	0006955	biological_process	immune response
r	0008198	molecular_function	ferrous iron binding
r	0008199	molecular_function	ferric iron binding
r	0008285	biological_process	negative regulation of cell population proliferation
r	0016491	molecular_function	oxidoreductase activity
r	0031410	cellular_component	cytoplasmic vesicle
r	0042802	molecular_function	identical protein binding
r	0044754	cellular_component	autolysosome
r	0046872	molecular_function	metal ion binding
r	0048147	biological_process	negative regulation of fibroblast proliferation
r	0070062	cellular_component	extracellular exosome
r	0070288	cellular_component	ferritin complex
r	0110076	biological_process	negative regulation of ferroptosis
r	0140315	molecular_function	iron ion sequestering activity
r	1904724	cellular_component	tertiary granule lumen
r	1904813	cellular_component	ficolin-1-rich granule lumen
s	0004322	molecular_function	ferroxidase activity
s	0005506	molecular_function	iron ion binding
s	0005515	molecular_function	protein binding
s	0005576	cellular_component	extracellular region
s	0005634	cellular_component	nucleus
s	0005737	cellular_component	cytoplasm
s	0005764	cellular_component	lysosome
s	0005776	cellular_component	autophagosome
s	0005829	cellular_component	cytosol
s	0006826	biological_process	iron ion transport
s	0006879	biological_process	intracellular iron ion homeostasis
s	0006955	biological_process	immune response
s	0008198	molecular_function	ferrous iron binding
s	0008199	molecular_function	ferric iron binding
s	0008285	biological_process	negative regulation of cell population proliferation
s	0016491	molecular_function	oxidoreductase activity
s	0031410	cellular_component	cytoplasmic vesicle
s	0042802	molecular_function	identical protein binding
s	0044754	cellular_component	autolysosome
s	0046872	molecular_function	metal ion binding
s	0048147	biological_process	negative regulation of fibroblast proliferation
s	0070062	cellular_component	extracellular exosome
s	0070288	cellular_component	ferritin complex
s	0110076	biological_process	negative regulation of ferroptosis
s	0140315	molecular_function	iron ion sequestering activity
s	1904724	cellular_component	tertiary granule lumen
s	1904813	cellular_component	ficolin-1-rich granule lumen
t	0004322	molecular_function	ferroxidase activity
t	0005506	molecular_function	iron ion binding
t	0005515	molecular_function	protein binding
t	0005576	cellular_component	extracellular region
t	0005634	cellular_component	nucleus
t	0005737	cellular_component	cytoplasm
t	0005764	cellular_component	lysosome
t	0005776	cellular_component	autophagosome
t	0005829	cellular_component	cytosol
t	0006826	biological_process	iron ion transport
t	0006879	biological_process	intracellular iron ion homeostasis
t	0006955	biological_process	immune response
t	0008198	molecular_function	ferrous iron binding
t	0008199	molecular_function	ferric iron binding
t	0008285	biological_process	negative regulation of cell population proliferation
t	0016491	molecular_function	oxidoreductase activity
t	0031410	cellular_component	cytoplasmic vesicle
t	0042802	molecular_function	identical protein binding
t	0044754	cellular_component	autolysosome
t	0046872	molecular_function	metal ion binding
t	0048147	biological_process	negative regulation of fibroblast proliferation
t	0070062	cellular_component	extracellular exosome
t	0070288	cellular_component	ferritin complex
t	0110076	biological_process	negative regulation of ferroptosis
t	0140315	molecular_function	iron ion sequestering activity
t	1904724	cellular_component	tertiary granule lumen
t	1904813	cellular_component	ficolin-1-rich granule lumen
u	0004322	molecular_function	ferroxidase activity
u	0005506	molecular_function	iron ion binding
u	0005515	molecular_function	protein binding
u	0005576	cellular_component	extracellular region
u	0005634	cellular_component	nucleus
u	0005737	cellular_component	cytoplasm
u	0005764	cellular_component	lysosome
u	0005776	cellular_component	autophagosome
u	0005829	cellular_component	cytosol
u	0006826	biological_process	iron ion transport
u	0006879	biological_process	intracellular iron ion homeostasis
u	0006955	biological_process	immune response
u	0008198	molecular_function	ferrous iron binding
u	0008199	molecular_function	ferric iron binding
u	0008285	biological_process	negative regulation of cell population proliferation
u	0016491	molecular_function	oxidoreductase activity
u	0031410	cellular_component	cytoplasmic vesicle
u	0042802	molecular_function	identical protein binding
u	0044754	cellular_component	autolysosome
u	0046872	molecular_function	metal ion binding
u	0048147	biological_process	negative regulation of fibroblast proliferation
u	0070062	cellular_component	extracellular exosome
u	0070288	cellular_component	ferritin complex
u	0110076	biological_process	negative regulation of ferroptosis
u	0140315	molecular_function	iron ion sequestering activity
u	1904724	cellular_component	tertiary granule lumen
u	1904813	cellular_component	ficolin-1-rich granule lumen
v	0004322	molecular_function	ferroxidase activity
v	0005506	molecular_function	iron ion binding
v	0005515	molecular_function	protein binding
v	0005576	cellular_component	extracellular region
v	0005634	cellular_component	nucleus
v	0005737	cellular_component	cytoplasm
v	0005764	cellular_component	lysosome
v	0005776	cellular_component	autophagosome
v	0005829	cellular_component	cytosol
v	0006826	biological_process	iron ion transport
v	0006879	biological_process	intracellular iron ion homeostasis
v	0006955	biological_process	immune response
v	0008198	molecular_function	ferrous iron binding
v	0008199	molecular_function	ferric iron binding
v	0008285	biological_process	negative regulation of cell population proliferation
v	0016491	molecular_function	oxidoreductase activity
v	0031410	cellular_component	cytoplasmic vesicle
v	0042802	molecular_function	identical protein binding
v	0044754	cellular_component	autolysosome
v	0046872	molecular_function	metal ion binding
v	0048147	biological_process	negative regulation of fibroblast proliferation
v	0070062	cellular_component	extracellular exosome
v	0070288	cellular_component	ferritin complex
v	0110076	biological_process	negative regulation of ferroptosis
v	0140315	molecular_function	iron ion sequestering activity
v	1904724	cellular_component	tertiary granule lumen
v	1904813	cellular_component	ficolin-1-rich granule lumen
w	0004322	molecular_function	ferroxidase activity
w	0005506	molecular_function	iron ion binding
w	0005515	molecular_function	protein binding
w	0005576	cellular_component	extracellular region
w	0005634	cellular_component	nucleus
w	0005737	cellular_component	cytoplasm
w	0005764	cellular_component	lysosome
w	0005776	cellular_component	autophagosome
w	0005829	cellular_component	cytosol
w	0006826	biological_process	iron ion transport
w	0006879	biological_process	intracellular iron ion homeostasis
w	0006955	biological_process	immune response
w	0008198	molecular_function	ferrous iron binding
w	0008199	molecular_function	ferric iron binding
w	0008285	biological_process	negative regulation of cell population proliferation
w	0016491	molecular_function	oxidoreductase activity
w	0031410	cellular_component	cytoplasmic vesicle
w	0042802	molecular_function	identical protein binding
w	0044754	cellular_component	autolysosome
w	0046872	molecular_function	metal ion binding
w	0048147	biological_process	negative regulation of fibroblast proliferation
w	0070062	cellular_component	extracellular exosome
w	0070288	cellular_component	ferritin complex
w	0110076	biological_process	negative regulation of ferroptosis
w	0140315	molecular_function	iron ion sequestering activity
w	1904724	cellular_component	tertiary granule lumen
w	1904813	cellular_component	ficolin-1-rich granule lumen
x	0004322	molecular_function	ferroxidase activity
x	0005506	molecular_function	iron ion binding
x	0005515	molecular_function	protein binding
x	0005576	cellular_component	extracellular region
x	0005634	cellular_component	nucleus
x	0005737	cellular_component	cytoplasm
x	0005764	cellular_component	lysosome
x	0005776	cellular_component	autophagosome
x	0005829	cellular_component	cytosol
x	0006826	biological_process	iron ion transport
x	0006879	biological_process	intracellular iron ion homeostasis
x	0006955	biological_process	immune response
x	0008198	molecular_function	ferrous iron binding
x	0008199	molecular_function	ferric iron binding
x	0008285	biological_process	negative regulation of cell population proliferation
x	0016491	molecular_function	oxidoreductase activity
x	0031410	cellular_component	cytoplasmic vesicle
x	0042802	molecular_function	identical protein binding
x	0044754	cellular_component	autolysosome
x	0046872	molecular_function	metal ion binding
x	0048147	biological_process	negative regulation of fibroblast proliferation
x	0070062	cellular_component	extracellular exosome
x	0070288	cellular_component	ferritin complex
x	0110076	biological_process	negative regulation of ferroptosis
x	0140315	molecular_function	iron ion sequestering activity
x	1904724	cellular_component	tertiary granule lumen
x	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLADFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP126-LYS146

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7152
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1992356","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FHA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	144
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Site: {"description":"Essential for association with cargo receptor NCOA4","evidences":[{"source":"PubMed","id":"26436293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---