7JGH

Cryo-EM structure of P. falciparum VAR2CSA NF54 core in complex with CSA at 3.36 A

Summary for 7JGH

• Entry DOI: 10.2210/pdb7jgh/pdb
• EMDB information: 22323 22324 22325 22326 22327
• Descriptor: Erythrocyte membrane protein 1, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose (3 entities in total)
• Functional Keywords: placental malaria, var2csa, duffy binding domain, csa, pfemp1, sugar binding protein
• Biological source: Plasmodium falciparum (isolate NF54)
• Total number of polymer chains: 1
• Total formula weight: 311498.34

Authors

Ma, R.,Tolia, N.H. (deposition date: 2020-07-19, release date: 2021-01-13, Last modification date: 2021-03-10)

• Primary citation: Ma, R.,Lian, T.,Huang, R.,Renn, J.P.,Petersen, J.D.,Zimmerberg, J.,Duffy, P.E.,Tolia, N.H.; Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.; Nat Microbiol, 6:380-391, 2021; PubMed: 33452495; DOI: 10.1038/s41564-020-00858-9

Experimental method

ELECTRON MICROSCOPY (3.36 Å)