7JGH

Cryo-EM structure of P. falciparum VAR2CSA NF54 core in complex with CSA at 3.36 A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Erythrocyte membrane protein 1	polymer	2653	308706.0	1	UniProt (W7K270) Pfam (PF15448) Pfam (PF05424) Pfam (PF03011) In PDB	Plasmodium falciparum (isolate NF54)
2	B	beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid	branched		2491.0	1	In PDB GlyTouCan (G46693HA)
3	A	2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose	non-polymer		301.3	1	Chemie (ASG)

Sequence modifications

A: 1 - 2642 (UniProt: W7K270)

PDB	External Database	Details
Thr -1	-	expression tag
Gly 0	-	expression tag
Gly 2643	-	expression tag
Thr 2644	-	expression tag
Lys 2645	-	expression tag
His 2646	-	expression tag
His 2647	-	expression tag
His 2648	-	expression tag
His 2649	-	expression tag
His 2650	-	expression tag
His 2651	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	308706.0
Branched	Number of molecules	1
	Total formula weight	2491.0
Non-Polymers*	Number of molecules	1
	Total formula weight	301.3
All*	Total formula weight	311498.3

*Water molecules are not included.