7JGH

Cryo-EM structure of P. falciparum VAR2CSA NF54 core in complex with CSA at 3.36 A

7JGH の概要

• エントリーDOI: 10.2210/pdb7jgh/pdb
• EMDBエントリー: 22323 22324 22325 22326 22327
• 分子名称: Erythrocyte membrane protein 1, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose (3 entities in total)
• 機能のキーワード: placental malaria, var2csa, duffy binding domain, csa, pfemp1, sugar binding protein
• 由来する生物種: Plasmodium falciparum (isolate NF54)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 311498.34

構造登録者

Ma, R.,Tolia, N.H. (登録日: 2020-07-19, 公開日: 2021-01-13, 最終更新日: 2021-03-10)

• 主引用文献: Ma, R.,Lian, T.,Huang, R.,Renn, J.P.,Petersen, J.D.,Zimmerberg, J.,Duffy, P.E.,Tolia, N.H.; Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.; Nat Microbiol, 6:380-391, 2021; PubMed: 33452495; DOI: 10.1038/s41564-020-00858-9

実験手法

ELECTRON MICROSCOPY (3.36 Å)