7I91

Crystal Structure of 13 bound to the PH domain of Btk

This is a non-PDB format compatible entry.

Summary for 7I91

• Entry DOI: 10.2210/pdb7i91/pdb
• Group deposition: Btk ph domain (G_1002333)
• Descriptor: Tyrosine-protein kinase BTK, (6~{R})-6-(1-oxidanylpyridin-2-yl)-4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: fragment based drug discovery, ph domain, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 80983.14

Authors

Brear, P.,West, R.M.,Nicolescu, R.C.B.,Blaszczyk, B.K.,Anwar, A.,Deingruber, T.,Sanders, M.G.,Perez-Areales, F.J.,Stephens, L.R.,Hawkins, P.T.,Spring, D.R.,Hyvonen, M. (deposition date: 2025-03-24, release date: 2026-05-20)

• Primary citation: Brear, P.,West, R.M.,Nicolescu, R.C.B.,Blaszczyk, B.K.,Anwar, A.,Deingruber, T.,Sanders, M.G.,Perez-Areales, F.J.,Stephens, L.R.,Hawkins, P.T.,Spring, D.R.,Hyvonen, M.; Inhibition of a Pleckstrin Homology Domain by Lysine-reactive Covalent Inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)