7HVP

X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR

7HVP の概要

• エントリーDOI: 10.2210/pdb7hvp/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000228
• 分子名称: HIV-1 PROTEASE, INHIBITOR ACE-SER-LEU-ASN-PHE-PSI(CH(OH)-CH2N)-PRO-ILE VME (JG-365) (3 entities in total)
• 機能のキーワード: acid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22374.31

構造登録者

Swain, A.L.,Miller, M.M.,Green, J.,Rich, D.H.,Schneider, J.,Kent, S.B.H.,Wlodawer, A. (登録日: 1990-09-13, 公開日: 1993-07-15, 最終更新日: 2023-11-15)

• 主引用文献: Swain, A.L.,Miller, M.M.,Green, J.,Rich, D.H.,Schneider, J.,Kent, S.B.,Wlodawer, A.; X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.; Proc.Natl.Acad.Sci.USA, 87:8805-8809, 1990; PubMed: 2247451; DOI: 10.1073/pnas.87.22.8805

実験手法

X-RAY DIFFRACTION (2.4 Å)