7GQS

Crystal Structure of Werner helicase fragment 517-945 in complex with ADP

Summary for 7GQS

• Entry DOI: 10.2210/pdb7gqs/pdb
• Group deposition: To be published (G_1002280)
• Descriptor: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase, dna helicase, werner syndrome, recq protein-like 2, atp-dependent helicase, bifunctional 3'-5' exonuclease/atp-dependent helicase, wrn werner syndrome protein, recq-like type 3
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 50988.77

Authors

Classen, M.,Benz, J.,Brugger, D.,Rudolph, M.G. (deposition date: 2023-10-19, release date: 2024-05-01, Last modification date: 2024-05-29)

• Primary citation: Baltgalvis, K.A.,Lamb, K.N.,Symons, K.T.,Wu, C.C.,Hoffman, M.A.,Snead, A.N.,Song, X.,Glaza, T.,Kikuchi, S.,Green, J.C.,Rogness, D.C.,Lam, B.,Rodriguez-Aguirre, M.E.,Woody, D.R.,Eissler, C.L.,Rodiles, S.,Negron, S.M.,Bernard, S.M.,Tran, E.,Pollock, J.,Tabatabaei, A.,Contreras, V.,Williams, H.N.,Pastuszka, M.K.,Sigler, J.J.,Pettazzoni, P.,Rudolph, M.G.,Classen, M.,Brugger, D.,Claiborne, C.,Plancher, J.M.,Cuartas, I.,Seoane, J.,Burgess, L.E.,Abraham, R.T.,Weinstein, D.S.,Simon, G.M.,Patricelli, M.P.,Kinsella, T.M.; Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.; Nature, 629:435-442, 2024; PubMed: 38658751; DOI: 10.1038/s41586-024-07318-y

Experimental method

X-RAY DIFFRACTION (1.57 Å)