7FWF

Crystal Structure of human FABP4 binding site mutated to that of FABP5 in complex with 5-cyclohexyl-6-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)pyridine-3-carboxylic acid, i.e. SMILES c1(c(nc(c(c1)C(=O)O)C(F)(F)F)OCC(F)(F)F)C1CCCCC1 with IC50=0.733066 microM

Summary for 7FWF

Entry DOI	10.2210/pdb7fwf/pdb
Group deposition	To be published (G_1002264)
Descriptor	Fatty acid-binding protein, adipocyte, DIMETHYL SULFOXIDE, 5-cyclohexyl-6-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)pyridine-3-carboxylic acid, ... (4 entities in total)
Functional Keywords	lipid binding protein, fatty acid binding protein, cytoplasm, lipid-binding, transport, protein binding
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	15617.92
Authors	Ehler, A.,Benz, J.,Obst, U.,Richter, H.,Rudolph, M.G. (deposition date: 2023-04-27, release date: 2023-06-14, Last modification date: 2024-11-20)
Primary citation	Obst, U.,Magnone, C.,Kuhn, B.,Rudolph, M.G. Crystal Structure of a human FABP4 binding site mutated to that of FABP5 complex To be published,
Experimental method	X-RAY DIFFRACTION (1.24 Å)

Structure validation