7FVH

PanDDA analysis group deposition -- PHIP in complex with Z5067911819

Summary for 7FVH

Entry DOI	10.2210/pdb7fvh/pdb
Group deposition	PanDDA analysis group deposition (G_1002265)
Descriptor	PH-interacting protein, (2R)-4-(furan-3-carbonyl)-N-(4-methoxyphenyl)-2-methylpiperazine-1-carboxamide (3 entities in total)
Functional Keywords	false negatives, ligand features, rescreening, catalogue, fragment follow-ups, automated chemistry, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	17971.24
Authors	Grosjean, H.,Tomlinson, C.,Bradshaw, W.J.,Koekemoer, L.,Krojer, T.,Fearon, D.,Biggin, P.C.,von Delft, F. (deposition date: 2023-03-09, release date: 2023-03-29, Last modification date: 2026-01-21)
Primary citation	Grosjean, H.,Fieseler, K.K.,Sanchez-Garcia, R.,Thompson, W.,Deane, C.M.,von Delft, F.,Biggin, P.C. Structure-activity relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures Chem Sci, 2026 Cited by DOI: 10.1039/D5SC04919A PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation