7FS5

Structure of liver pyruvate kinase in complex with allosteric modulator 17

Summary for 7FS5

Entry DOI	10.2210/pdb7fs5/pdb
Group deposition	Sulfonamide-containing catechols as modulators of liver pyruvate kinase (G_1002240)
Descriptor	Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALATE ION, ... (7 entities in total)
Functional Keywords	pyruvate kinase, active site, inhibition, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	392445.53
Authors	Lulla, A.,Nilsson, O.,Brear, P.,Nain-Perez, A.,Grotli, M.,Hyvonen, M. (deposition date: 2022-12-18, release date: 2023-04-12)
Primary citation	Nain-Perez, A.,Nilsson, O.,Lulla, A.,Haversen, L.,Brear, P.,Liljenberg, S.,Hyvonen, M.,Boren, J.,Grotli, M. Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators. Eur.J.Med.Chem., 250:115177-115177, 2023 Cited by PubMed: 36753880 DOI: 10.1016/j.ejmech.2023.115177 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.182 Å)

Structure validation