7FQH

Crystal Structure of human Legumain in complex with (2S)-N-[(3S)-5-amino-5-oxopent-1-yn-3-yl]-1-[1-[4-(cyclopropylmethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

7FQH の概要

• エントリーDOI: 10.2210/pdb7fqh/pdb
• Group deposition: To be published (G_1002245)
• 分子名称: Legumain, N-[(3S)-5-amino-5-oxopent-1-en-3-yl]-1-{1-[4-(cyclopropylmethoxy)phenyl]cyclopropane-1-carbonyl}-L-prolinamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: cysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 154476.13

構造登録者

Ehler, A.,Benz, J.,Bartels, B.,Hewings-David, S.,Rudolph, M.G. (登録日: 2022-10-05, 公開日: 2023-10-11, 最終更新日: 2026-02-18)

• 主引用文献: Bartels, B.,Kuhn, B.,Benz, J.,Rudolph, M.G.; Crystal Structure of a human Legumain complex; To be published,

実験手法

X-RAY DIFFRACTION (2.18 Å)