7FLO
PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P05F11 from the F2X-Universal Library
Summary for 7FLO
| Entry DOI | 10.2210/pdb7flo/pdb |
| Group deposition | PanDDA analysis group deposition (G_1002241) |
| Descriptor | Pre-mRNA-splicing factor 8, A1 cistron-splicing factor AAR2, 2-methoxybenzamide, ... (4 entities in total) |
| Functional Keywords | fragmax, fragmaxapp, fragment screening, rnaseh like domain, u5 snrnp assembly, splicing |
| Biological source | Saccharomyces cerevisiae S288C More |
| Total number of polymer chains | 2 |
| Total formula weight | 65862.11 |
| Authors | Barthel, T.,Wollenhaupt, J.,Lima, G.M.A.,Wahl, M.C.,Weiss, M.S. (deposition date: 2022-08-26, release date: 2022-11-02, Last modification date: 2022-11-30) |
| Primary citation | Barthel, T.,Wollenhaupt, J.,Lima, G.M.A.,Wahl, M.C.,Weiss, M.S. Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J.Med.Chem., 65:14630-14641, 2022 Cited by PubMed: 36260741DOI: 10.1021/acs.jmedchem.2c01165 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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