7FH2

Crystal structure of the first bromodomain of BRD4 in complex with 16D10

7FH2 の概要

• エントリーDOI: 10.2210/pdb7fh2/pdb
• 分子名称: Bromodomain-containing protein 4, N-[2-[2-[(E)-3-(2,5-dimethoxyphenyl)prop-2-enoyl]-4,5-dimethoxy-phenyl]ethyl]ethanamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, bromodomain, brd4, histone, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66437.92

構造登録者

Yokoyama, T.,Hirasawa, N. (登録日: 2021-07-29, 公開日: 2022-08-03, 最終更新日: 2023-11-29)

• 主引用文献: Segawa, R.,Takeda, H.,Yokoyama, T.,Ishida, M.,Miyata, C.,Saito, T.,Ishihara, R.,Nakagita, T.,Sasano, Y.,Kanoh, N.,Iwabuchi, Y.,Mizuguchi, M.,Hiratsuka, M.,Hirasawa, N.; A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins.; Biochem Pharmacol, 194:114819-114819, 2021; PubMed: 34757034; DOI: 10.1016/j.bcp.2021.114819

実験手法

X-RAY DIFFRACTION (2.492 Å)