7FGX
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (TgDHFR-TS) complexed with P39, NADPH and dUMP
Summary for 7FGX
| Entry DOI | 10.2210/pdb7fgx/pdb |
| Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-hexyl-5-phenyl-pyrimidine-2,4-diamine, ... (5 entities in total) |
| Functional Keywords | toxoplasma gondii, dihydrofolate reductase, thymidylate synthase, antifolate, oxidoreductase |
| Biological source | Toxoplasma gondii |
| Total number of polymer chains | 4 |
| Total formula weight | 280666.53 |
| Authors | Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Yuvaniyama, J.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. (deposition date: 2021-07-28, release date: 2022-06-29, Last modification date: 2023-11-29) |
| Primary citation | Vanichtanankul, J.,Yoomuang, A.,Taweechai, S.,Saeyang, T.,Pengon, J.,Yuvaniyama, J.,Tarnchompoo, B.,Yuthavong, Y.,Kamchonwongpaisan, S. Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase. Acs Chem.Biol., 17:1691-1702, 2022 Cited by PubMed: 35715223DOI: 10.1021/acschembio.1c00627 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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