7FEH
Crystal structure of human DDR1 in complex with CH5541127
Summary for 7FEH
Entry DOI | 10.2210/pdb7feh/pdb |
Descriptor | Epithelial discoidin domain-containing receptor 1, N-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide, NITRATE ION, ... (4 entities in total) |
Functional Keywords | receptor tyrosine kinase, collagen, discoidin domain, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36840.60 |
Authors | Fukami, T.A.,Kadono, S.,Matsuura, T. (deposition date: 2021-07-20, release date: 2022-07-27, Last modification date: 2024-05-29) |
Primary citation | Kuhn, B.,Ritter, M.,Benz, J.,Kocer, B.,Sarie, J.C.,Hochstrasser, R.,Rudolph, M.G.,Kadono, S.,Matsuura, T.,Murata, T.,Richter, H.,Prunotto, M. Novel potent and highly selective DDR1 inhibitors from integrated lead finding Medicinal Chemistry Research, 32:1400-1425, 2023 Cited by DOI: 10.1007/s00044-023-03066-2PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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