7FEE

Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1

7FEE の概要

• エントリーDOI: 10.2210/pdb7fee/pdb
• 分子名称: Cannabinoid receptor 1,GlgA glycogen synthase, CHOLESTEROL, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, ... (9 entities in total)
• 機能のキーワード: signal protein, membrane protein, gpcr
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 67500.21

構造登録者

Wang, X.,Zhao, C.,Shao, Z. (登録日: 2021-07-19, 公開日: 2022-06-15, 最終更新日: 2024-04-03)

• 主引用文献: Yang, X.,Wang, X.,Xu, Z.,Wu, C.,Zhou, Y.,Wang, Y.,Lin, G.,Li, K.,Wu, M.,Xia, A.,Liu, J.,Cheng, L.,Zou, J.,Yan, W.,Shao, Z.,Yang, S.; Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.; Nat.Chem.Biol., 18:831-840, 2022; PubMed: 35637350; DOI: 10.1038/s41589-022-01038-y

実験手法

X-RAY DIFFRACTION (2.7 Å)