7F97
Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97
Summary for 7F97
Entry DOI | 10.2210/pdb7f97/pdb |
Descriptor | Proline--tRNA ligase, PROLINE, 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ... (7 entities in total) |
Functional Keywords | protein translation, malaria, inhibitor, prs, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Plasmodium falciparum 3D7 |
Total number of polymer chains | 4 |
Total formula weight | 234138.22 |
Authors | Mishra, S.,Malhotra, N.,Manickam, Y.,Sharma, A. (deposition date: 2021-07-04, release date: 2023-01-04, Last modification date: 2024-05-29) |
Primary citation | Mishra, S.,Malhotra, N.,Manickam, Y.,Sharma, A. Plasmodium falciparum Prolyl-tRNA Synthetase (PfPRS) in Complex with L-proline and compound L97 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.394 Å) |
Structure validation
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