7F8H

Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase

Summary for 7F8H

Entry DOI	10.2210/pdb7f8h/pdb
Descriptor	Eyes absent homolog 2, 3-fluoranyl-~{N}-[(~{E})-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide (2 entities in total)
Functional Keywords	eya2, eyes absent protein, phosphatase, transcription coactivator, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	3
Total formula weight	100103.12
Authors	Anantharajan, J.,Baburajendran, N. (deposition date: 2021-07-02, release date: 2021-12-29, Last modification date: 2023-11-29)
Primary citation	Anantharajan, J.,Baburajendran, N.,Lin, G.,Loh, Y.Y.,Xu, W.,Ahmad, N.H.B.,Liu, S.,Jansson, A.E.,Kuan, J.W.L.,Ng, E.Y.,Yeo, Y.K.,Hung, A.W.,Joy, J.,Hill, J.,Ford, H.L.,Zhao, R.,Keller, T.H.,Kang, C. Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase. Protein Sci., 31:422-431, 2022 Cited by PubMed: 34761455 DOI: 10.1002/pro.4234 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation