7F8H

Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase

7F8H の概要

• エントリーDOI: 10.2210/pdb7f8h/pdb
• 分子名称: Eyes absent homolog 2, 3-fluoranyl-~{N}-[(~{E})-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide (2 entities in total)
• 機能のキーワード: eya2, eyes absent protein, phosphatase, transcription coactivator, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 100103.12

構造登録者

Anantharajan, J.,Baburajendran, N. (登録日: 2021-07-02, 公開日: 2021-12-29, 最終更新日: 2023-11-29)

• 主引用文献: Anantharajan, J.,Baburajendran, N.,Lin, G.,Loh, Y.Y.,Xu, W.,Ahmad, N.H.B.,Liu, S.,Jansson, A.E.,Kuan, J.W.L.,Ng, E.Y.,Yeo, Y.K.,Hung, A.W.,Joy, J.,Hill, J.,Ford, H.L.,Zhao, R.,Keller, T.H.,Kang, C.; Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase.; Protein Sci., 31:422-431, 2022; PubMed: 34761455; DOI: 10.1002/pro.4234

実験手法

X-RAY DIFFRACTION (3.3 Å)