7EZW

Cyclic Peptide that Interacts with the eIF4E Capped-mRNA Binding Site

7EZW の概要

• エントリーDOI: 10.2210/pdb7ezw/pdb
• 分子名称: Eukaryotic translation initiation factor 4E, ALA-CYS-GLU-MET-GLY-PHE-PHE-GLN-ASP-CYS-GLY, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: ap dependent translation, rna binding protein-inhibitor complex, rna binding protein/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26358.60

構造登録者

Brown, C.J.,Ng, S.,Frosi, Y. (登録日: 2021-06-02, 公開日: 2022-06-08, 最終更新日: 2023-11-29)

• 主引用文献: Frosi, Y.,Ng, S.,Lin, Y.C.,Jiang, S.,Ramlan, S.R.,Lama, D.,Verma, C.S.,Asial, I.,Brown, C.J.; Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE).; Rsc Chem Biol, 3:916-930, 2022; PubMed: 35866173; DOI: 10.1039/d2cb00099g

実験手法

X-RAY DIFFRACTION (2.35 Å)