7EX6

Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 11

Summary for 7EX6

• Entry DOI: 10.2210/pdb7ex6/pdb
• Descriptor: Replicase, MANGANESE (II) ION, methyl (Z)-4-(4-(4-chlorobenzyl)-1-(2-methylbenzyl)piperidin-4-yl)-2-hydroxy-4-oxobut-2-enoate, ... (4 entities in total)
• Functional Keywords: endonuclease, hydrolase
• Biological source: Abbey lake orthobunyavirus
• Total number of polymer chains: 4
• Total formula weight: 102934.79

Authors

Kuang, W.,Hu, Z.,Gong, P. (deposition date: 2021-05-26, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z.; Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ).; J.Virol., 96:e0217321-e0217321, 2022; PubMed: 35266805; DOI: 10.1128/jvi.02173-21

Experimental method

X-RAY DIFFRACTION (2.18 Å)