7EX2

Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with L-742,001 (methyl ester form)

Summary for 7EX2

• Entry DOI: 10.2210/pdb7ex2/pdb
• Descriptor: Replicase, MANGANESE (II) ION, methyl (Z)-4-[4-[(4-chlorophenyl)methyl]-1-(phenylmethyl)piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoate (3 entities in total)
• Functional Keywords: endonuclease, hydrolase
• Biological source: Abbey lake orthobunyavirus
• Total number of polymer chains: 2
• Total formula weight: 51439.34

Authors

Kuang, W.,Hu, Z.,Gong, P. (deposition date: 2021-05-26, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z.; Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ).; J.Virol., 96:e0217321-e0217321, 2022; PubMed: 35266805; DOI: 10.1128/jvi.02173-21

Experimental method

X-RAY DIFFRACTION (3.1 Å)