7EWH

Crystal structure of human PHGDH in complex with Homoharringtonine

Summary for 7EWH

Entry DOI	10.2210/pdb7ewh/pdb
Descriptor	D-3-phosphoglycerate dehydrogenase, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine (3 entities in total)
Functional Keywords	inhibitor, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	66000.01
Authors	Hsieh, C.H.,Cheng, Y.S.,Lee, Y.S.,Huang, H.C.,Juan, H.F. (deposition date: 2021-05-25, release date: 2022-12-07, Last modification date: 2023-12-20)
Primary citation	Hsieh, C.H.,Huang, C.T.,Cheng, Y.S.,Hsu, C.H.,Hsu, W.M.,Chung, Y.H.,Liu, Y.L.,Yang, T.S.,Chien, C.Y.,Lee, Y.H.,Huang, H.C.,Juan, H.F. Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma. Biomed Pharmacother, 166:115429-115429, 2023 Cited by PubMed: 37673018 DOI: 10.1016/j.biopha.2023.115429 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.99 Å)

Structure validation