7EWH

Crystal structure of human PHGDH in complex with Homoharringtonine

7EWH の概要

• エントリーDOI: 10.2210/pdb7ewh/pdb
• 分子名称: D-3-phosphoglycerate dehydrogenase, (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine (3 entities in total)
• 機能のキーワード: inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66000.01

構造登録者

Hsieh, C.H.,Cheng, Y.S.,Lee, Y.S.,Huang, H.C.,Juan, H.F. (登録日: 2021-05-25, 公開日: 2022-12-07, 最終更新日: 2023-12-20)

• 主引用文献: Hsieh, C.H.,Huang, C.T.,Cheng, Y.S.,Hsu, C.H.,Hsu, W.M.,Chung, Y.H.,Liu, Y.L.,Yang, T.S.,Chien, C.Y.,Lee, Y.H.,Huang, H.C.,Juan, H.F.; Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma.; Biomed Pharmacother, 166:115429-115429, 2023; PubMed: 37673018; DOI: 10.1016/j.biopha.2023.115429

実験手法

X-RAY DIFFRACTION (2.99 Å)