7EW1
Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 5 in complex with Gi protein
Summary for 7EW1
Entry DOI | 10.2210/pdb7ew1/pdb |
EMDB information | 31344 |
Descriptor | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total) |
Functional Keywords | homo sapiens, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 159201.60 |
Authors | Yuan, Y.,Jia, G.W.,Shao, Z.H.,Su, Z.M. (deposition date: 2021-05-24, release date: 2021-09-29, Last modification date: 2022-02-16) |
Primary citation | Yuan, Y.,Jia, G.,Wu, C.,Wang, W.,Cheng, L.,Li, Q.,Li, Z.,Luo, K.,Yang, S.,Yan, W.,Su, Z.,Shao, Z. Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31:1263-1274, 2021 Cited by PubMed: 34526663DOI: 10.1038/s41422-021-00566-x PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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