7EU5
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with tricyclic small molecule inhibitor JBSNF-000107
Summary for 7EU5
Entry DOI | 10.2210/pdb7eu5/pdb |
Descriptor | Nicotinamide N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 6-fluoranyl-10-methyl-1,10-diazatricyclo[6.3.1.0^{4,12}]dodeca-4,6,8(12)-trien-11-imine, ... (4 entities in total) |
Functional Keywords | nnmt, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 127305.44 |
Authors | Swaminathan, S.,Gosu, R.,Birudukota, S.,Kandan, S.,Vaithilingam, K. (deposition date: 2021-05-16, release date: 2022-05-18, Last modification date: 2023-11-29) |
Primary citation | Ruf, S.,Rajagopal, S.,Kadnur, S.V.,Hallur, M.S.,Rani, S.,Kristam, R.,Swaminathan, S.,Zope, B.R.,Gondrala, P.K.,Swamy, I.,Putta, V.P.R.K.,Kandan, S.,Zech, G.,Schreuder, H.,Rudolph, C.,Elvert, R.,Czech, J.,Birudukota, S.,Siddiqui, M.A.,Anand, N.N.,Mane, V.S.,Dittakavi, S.,Suresh, J.,Gosu, R.,Ramesh, M.,Yura, T.,Dhakshinamoorthy, S.,Kannt, A. Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep, 12:15440-15440, 2022 Cited by PubMed: 36104373DOI: 10.1038/s41598-022-19634-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.731 Å) |
Structure validation
Download full validation report