7ER9
Crystal structure of human Biliverdin IX-beta reductase B with Febuxostat (TEI)
Summary for 7ER9
Entry DOI | 10.2210/pdb7er9/pdb |
Descriptor | Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID, ... (5 entities in total) |
Functional Keywords | platelets, biliverdin reductase b, blvrb, inhibitors, nadp, febuxostat, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 49563.46 |
Authors | Griesinger, C.,Lee, D.,Ryu, K.S.,Kim, M.,Ha, J.H. (deposition date: 2021-05-06, release date: 2022-01-19, Last modification date: 2023-11-29) |
Primary citation | Kim, M.,Ha, J.H.,Choi, J.,Kim, B.R.,Gapsys, V.,Lee, K.O.,Jee, J.G.,Chakrabarti, K.S.,de Groot, B.L.,Griesinger, C.,Ryu, K.S.,Lee, D. Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target. J.Med.Chem., 65:2548-2557, 2022 Cited by PubMed: 34957824DOI: 10.1021/acs.jmedchem.1c01664 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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