7ER9

Crystal structure of human Biliverdin IX-beta reductase B with Febuxostat (TEI)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Flavin reductase (NADPH)	polymer	216	23529.8	2	UniProt (P30043) Pfam (PF13460)	Homo sapiens (Human)	FR,Biliverdin reductase B,BVR-B,Biliverdin-IX beta-reductase,Green heme-binding protein,GHBP,NADPH-dependent diaphorase,NADPH-flavin reductase,FLR
2	C, G (A, B)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	D, H (A, B)	2-(3-CYANO-4-ISOBUTOXY-PHENYL)-4-METHYL-5-THIAZOLE-CARBOXYLIC ACID	non-polymer		316.4	2	Chemie (TEI)
4	E, F, I, J (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
5	K, L (A, B)	water	water		18.0	463	Chemie (HOH)

Sequence modifications

A, B: 1 - 206 (UniProt: P30043)

PDB	External Database	Details
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47059.6
Non-Polymers*	Number of molecules	8
	Total formula weight	2503.8
All*	Total formula weight	49563.5

*Water molecules are not included.