7ER2

Crystal structure of EGFR 696-1022 T790M/C797S in complex with LS_2_40

Summary for 7ER2

• Entry DOI: 10.2210/pdb7er2/pdb
• Descriptor: Epidermal growth factor receptor, 5-chloranyl-N2-[3-chloranyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine (3 entities in total)
• Functional Keywords: egfr, t790m/c797s, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38048.88

Authors

Zhu, S.J.,Yun, C.H. (deposition date: 2021-05-05, release date: 2022-04-20, Last modification date: 2023-11-29)

• Primary citation: Li, S.,Zhang, T.,Zhu, S.J.,Lei, C.,Lai, M.,Peng, L.,Tong, L.,Pang, Z.,Lu, X.,Ding, J.,Ren, X.,Yun, C.H.,Xie, H.,Ding, K.; Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR T790M/C797S Mutants.; Acs Med.Chem.Lett., 13:196-202, 2022; PubMed: 35178175; DOI: 10.1021/acsmedchemlett.1c00555

Experimental method

X-RAY DIFFRACTION (2.662 Å)